Bioinformatics, Genome Evolution


BSc: Mathematics, Lanzhou University, 1983

MSc: Mathematics, Lanzhou University, 1990

PhD: Ecology, Lanzhou University, 1997


Research Interests

In my lab, we use the whole genome comparison methodologies to explore how the genomes of closely related species and populations might evolve. Currently, we are interested in modeling and analyzing population genomic datasets using colored de Bruijn graphs.


Selected Publications

♦ Research Articles

1. Cao,H., Pang,E. and Lin,K. (2016) Hierarchical Map of Orthologous Genomic Regions Reconstructed from Two Closely Related Genomes: Cucumber Case Study. Plant Genome, 9, 0.

2. Zhang,Y.-C., Zhang,Y., Zhu,B.-R., Zhang,B.-W., Ni,C., Zhang,D.-Y., Huang,Y., Pang,E. and Lin,K. (2015) Genome sequences of two closely related strains of Escherichia coli K-12 GM4792. Stand Genomic Sci, 10, 125.

3. Lin,K., Limpens,E., Zhang,Z., Ivanov,S., Saunders,D.G.O., Mu,D., Pang,E., Cao,H., Cha,H., Lin,T., et al. (2014) Single nucleus genome sequencing reveals high similarity among nuclei of an endomycorrhizal fungus. Plos Genet, 10, e1004078.

4. Zhang,Y. and Lin,K. (2012) A phylogenomic analysis of Escherichia coli / Shigella group: implications of genomic features associated with pathogenicity and ecological adaptation. BMC Evol. Biol., 12, 174.

5. Li,Z., Zhang,Z., Yan,P., Huang,S., Fei,Z. and Lin,K. (2011) RNA-Seq improves annotation of protein-coding genes in the cucumber genome. BMC Genomics, 12, 540.

6. Lin,K., Zhu,L. and Zhang,D.-Y. (2006) An initial strategy for comparing proteins at the domain architecture level. Bioinformatics, 22, 2081–2086.

7. Luo,Y., Fu,C., Zhang,D.-Y. and Lin,K. (2006) Overlapping genes as rare genomic markers: the phylogeny of gamma-Proteobacteria as a case study. Trends Genet., 22, 593–596.

8. Wu,X., Zhu,L., Guo,J., Zhang,D.-Y. and Lin,K. (2006) Prediction of yeast protein-protein interaction network: insights from the Gene Ontology and annotations. Nucleic Acids Res., 34, 2137–2150.


Contact Information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-10-58805045

E-mail: linkui@bnu.edu.cn