Professor

Biochemistry and Molecular Biology

 

1991-1996, B.S., Tsinghua University, China

1996-1998, M.S., Tsinghua University, China

1998-2011, Ph.D., Tsinghua University, China

2012-2014, Postdoc., The Max Planck Society, Germany

2014-present, Teacher, Beijing Normal University, China

 

Research Interests

1. Screening and using of scFv antibodies targeting the Tau protein in treating Alzheimer’s disease.

2. Study of molecular mechanism of protein folding and aggregation.

3. Study of function and molecular mechanism of chaperones and foldases (such as PPIases).

4. Study of structure and function of antibodies with novel application (such as chaperone).

5. Study of protein-protein interaction network and gene co-expression network in human diseases such as Alzheimer’s disease and cancer.

 

Selected Publications

♦ Research Articles

1. Tingting Liu, Caixian Sun, Cong Li, Jinhyuk Lee, Yong-Doo Park, Yixin Zhang*, and Sen Li*. Designing an antibody-based chaperoning system through programming the binding and release of the folding intermediate. ACS Chemical Biology, 2016, 11(4):1090−1097.

2. Yingying Wu, Ningning Teng, Sen Li*. Effects of macromolecular crowding and osmolyte on human Taufibrillation. International Journal of Biological Macromolecules, 2016, 90:27–36.

3. Sen Li*, Caixian Sun, Ningning Teng, Weili Yang, Lijun Zhou, and Yixin Zhang.  Chaperone-like effects of a scFv antibody on the folding of human muscle creatine kinase. Protein Engineering, Design & Selection, 2013, 26(8): 523–531.

4. Jianyu Feng, Hong Guo, Sen Li*, Tun Lu*. A Study of the Mechanism of the Chaperone-like Function of an scFv of Human Creatine Kinase by Computer Simulation. PLOS ONE, 2013, 8(4): e62147.

5. Sen Li*, Ji-Hong Bai, Yong-Doo Park and Hai-Meng Zhou*. Capture of monomeric refolding intermediate of human muscle creatine kinase. Protein Science, 2006, 15(1): 171-181.

 

Contact Information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-10-58802765

E-mail: lisen@bnu.edu.cn