Assciate Professor

Cell biology

2004-2008 Bachelor, College of Life Science, Wuhan University, China

2008-2013 Ph.D., Institute of Biophysics, Chinese Academy of Sciences (CAS), China

2013-2015 Research assistant professor, Institute of Genetics and Developmental Biology, CAS, China、、

2015-Present Lecturer/Associate Professor, Department of Cell Biology, College of Life Science, Beijing Normal University, China

2025-Present Member of the Animal Welfare and Ethics Committee, College of Life Sciences, Beijing Normal University, China

Research Interests

Protein Modifications and Degradation；Autophagy and Apoptosis；Metabolism and Tumorigenesis

 

Selected Publications

1.      Wan-Yu Yue^†; Yi Zhang^†; Tian-Xia Jiang*, et al.; Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility, Cells, 2025, May 12;14(10):696. (IF:5.2)

2.      Pei Wen, Yan Sun, Tian-Xia Jiang* and Xiao-Bo Qiu*, PA200-Mediated Proteasomal Protein Degradation and Regulation of Cellular Senescence. Int. J. Mol. Sci., 2024, 25, 5637.

3.      Shuo-Shuo Liu^†; Tian-Xia Jiang^†; Fan Bu^†; Ji-Lan Zhao^†; Guang-Fei Wang^†, et al.; Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy, Nature Communications, 2024, Jan 30;15(1):891.(IF:16.6)

4.      Zi-Yu Luo^†; Tian-Xia Jiang^†, et al.; Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis. Cells, 2023, 12, 2211 （IF:6.0）

5.      Chen YS, Han X, Lin K, Tian-Xia Jiang*, Qiu XB*. (2021). Proteasome Activator Blm10 Regulates Transcription Especially During Aging. Curr Genomics. 2021 Dec 16;22(4):306-317.

6.      Tian-Xia Jiang ^†, Ma Shuang^†, Han Xia^†, et al.. (2021). Proteasome activator PA200 maintains stability of histone marks during transcription and aging. Theranostics, 2021; 11(3): 1458-1472. doi: 10.7150/thno.48744. (IF:11.6)

7.      Zi-Hui Zhang, Tian-Xia Jiang*, et al.. (2021) Proteasome subunit a4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes. The Journal of Biological Chemistry, 2021 Jan-Jun;296:100130. (IF:4.23)

8.      Tian-Xia Jiang ^†, et al.. (2019). SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc. Natl. Acad. Sci. USA, 2019.116(27):13404-13413. (IF:9.5)

9.      Tian-Xia Jiang et al.; Substrate receptors of proteasomes. Biological Reviews, 2018, 93, 1765-1777. (IF:11.6)

10.  Tian-Xia Jiang, et al.. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood, 2012, Sep 13;120(11):2330-9. (IF:10.8)

(#Co-first authors, *Corresponding authors).

Patents

Use of Compound U37i as a Small-Molecule Inhibitor Targeting UCH37 and UCHL3. Beijing Normal University. Inventors: Xiaobo Qiu, Luming Zhou, Tian-Xia Jiang. Patent No.: ZL 2024 1 1120253.2. Date of Authorization: April 29, 2025.

Book Chapters

Qiu, X., Zhang, H., Wang, C., & Wang, L. (Eds.). Protein Degradation and Autophagy Mediated by the Ubiquitin Family. Science Press, 2020. (Member of the Editorial Board)

Research Projects / Grants

Presided over the National Natural Science Foundation of China (NSFC) for Young Scholars, the General Program of Beijing Natural Science Foundation, and served as a key member of a project under the National Key R&D Program of China. Participated in the Key Program of NSFC and industry-sponsored projects with pharmaceutical companies, etc.

Teaching Experience

Molecular Biology, Targeted Cancer Therapy and Human Health, Experimental Cell Biology

Current Graduate Students

Yang Guoheng, Dong Jiahui, Cai Bingkun, Jiang Chenyang, Gu Yu, Wang Zhiwei, Mao Weijia, Zhan Kedi

Contact information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

E-mail：jiangtx@bnu.edu.cn