Professor

 

Sept. 1981 - Jul. 1987  

Medicine Degree 

Shanghai Medical University

Shanghai, China,

Specialization: Public Health

 

Sept. 1987 - Jul. 1988  

Postgraduate Study: Human Genetics,

Shanghai Medical University

 

Sept. 1988 - Jun. 1989  

German Language Training

Guangzhou Languages Institute

Guangzhou, China

 

Oct. 1989 - Nov. 1992   

Ph.D student

Field: Human Genetics

Institute of Human Genetics

University Greifswald

Germany 

Dissertation: “Untersuchungen zur biochemischen und immunologischen Charakterisierung der Steroidsulfatase” on 1992-09-18.                  

Supervisor: Professor Falko Herrmann 

      

Dec. 1992 - Jun. 1997  

Post-doc

Field: Bacterial Infection Biology

Institute of Immunology and Transfusion Medicine

University Greifswald, Germany

Major achievements:

1) set up knock-out mice technology platform;

2) published a significant paper on bacterial infection biology in “ Nature”;

3) 1997 Science Prize by the German Paul-Ehrlich-Society.

 

Since Aug. 1997 ----  

Research Associate, assistant professor

Lund University, Medical Faculty

Sweden

2002----  Group leader

Sept 2004  Associate Docent of Molecular Medicine

Spring 2009 University Lektor of experimental oncology 

Field: Virology, Gene Therapy, Stem Cell and Cancer Cell Biology

Major achievements:

1) set up adenoviral vector generation and genetransfer technique platform;

2) set up independent research programs;

3) attract independent grant supports from Swedish Research Council, Swedish Cancer Society, and Swedish Pediatric Cancer Society.

 

Since September 2009

Professor

College of Life Sciences

Beijing Normal University

 

Research Interests

We aim to develop a brain development-guided molecular classification scheme for glioma. By searching for gene co-expression networks converged between brain development and glioma genesis, we have identified gene co-expression modules consistently co-expressed with EGFR or PDGFRA in glioma transcriptome, and developed a morphology-independent EM/PM classification scheme for adult diffuse gliomas. The current goal is to translate the EM/PM classification into a clinically applicable diagnostic tool and to identify therapy targets for the EM and PM molecular subtypes.

 

Selected Publications

♦ Research Articles

1. Sun Y, Zhang W, Chen D, Lv Y, Zheng J, Lilljebjörn H, Ran L, Bao Z, Soneson C, Sjögren H.O, Salford L.G, Ji J, French P.J, Fioretos T, Jiang T, and Fan X. A glioma classification scheme based on coexpression modules of EGFR and PDGFRA. PNAS 111:3538-3543, 2014.

2. Ayaz Ali Samo, Jiuyi Li, Min Zhou, Yingyu Sun, Yuan Yang, Yunqiu Zhang, Jing Li, Mark van Duin, Xuzhang Lu, and Xiaolong Fan. MCL1 gene co-expression module stratifies multiple myeloma and predicts response to proteasome inhibitor-based therapy. Genes, Chromosomes and Cancer . 2018. 57:420-429.

3. Huimin Hu, Quanhua Mu, Zhaoshi Bao, Yiyun Chen, Yanwei Liu, Jing Chen, Kuanyu Wang, Zheng Wang, Yoonhee Nam, Biaobin Jiang, Jason K. Sa, Hee-Jin Cho, Nam-Gu Her, Chuanbao Zhang, Zheng Zhao, Ying Zhang, Fan Zeng, Fan Wu, Xun Kang, Yuqing Liu, Zenghui Qian, Zhiliang Wang, Ruoyu Huang, Qiangwei Wang, Wei Zhang, Xiaoguang Qiu, Wenbin Li, Do-Hyun Nam, Xiaolong Fan*, Jiguang Wang*, Tao Jiang*. Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor. Cell 2018. 175: 1665-1678. (co-corresponding author)

4. Yunqiu Zhang, Jiuyi Li, Kaikai Yi, Jing Feng, Zhengmin Cong, Zheng Wang, Yanfei Wei, Fan Wu, Wen Cheng, Ayaz Ali Samo, Paolo Salomoni, Qiong Yang, Yu Huang, Chunsheng Kang, Tao Jiang, and Xiaolong Fan. Elevated signature of a gene module co-expressed with CDC20 marks genomic instability in glioma. PNAS 116:6975-6984, 2019.   

5. Jiuyi Li, Yang Xue, Anna Wenger, Yingyu Sun, Zheng Wang, Chuanbao Zhang, Yunqiu Zhang, Boglarka Fekete Rydenhag, Bertil Rydenhag, Asgeir Store Jakola, Tao Jiang, Helena Carén, and Xiaolong Fan. Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density Array. Clinical Cancer Research . In press, 2019.

 

Contact Information

School of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-13161252991

E-mail: xfan@bnu.edu.cn