Neurogenesis, Gliomas, Vocal plasticity


1992-1996, BSc, Beijing Normal University, China

1996-1999, MSc, Beijing Normal University, China

1999-2001, Teaching Assistant, Beijing Normal University, China

2001-2009, Lecturer, Beijing Normal University, China

2003-2008, Ph.D., Beijing Normal University, China

2006, Visiting Scholar, University of Illinois at Urbana-Champaign, IL, USA

2009-2019, Associate Professor, Beijing Normal University, China

2010, Visiting Scholar, Dept. of Neurosurgery, Lund University, Sweden

2013-2014, Visiting Scholar, Wallenberg Neuroscience Center, Lund University, Sweden

2019-present, Professor, Beijing Normal University, China


Research Interests

1. Adult neurogenesis, gliogenesis and gliomas: Neural progenitor/stem cells reside in the adult brain and continue to generate new neurons (neurogenesis) and glia (gliogenesis) throughout life. This endogenous process can be harnessed to repair the injured or diseased brain, while its dysregulation could lead to tumors, such as gliomas. We are interested in the cellular origin of gliomas. Establishing patient-derived glioma cell lines and using sequencing techniques, we try to uncover their initial transformation events. On the other hand, we concern about the adult neurogenesis in the striatum, a region that may be affected by a wide variety of disorders, such as stroke, Huntington’s disease, Parkinson’s disease, schizophrenia, and addiction. Using bird and rodent models, we try to clarify the internal and external factors that affect the striatal neurogenesis. 


2. Basal ganglia circuit and vocal plasticit: Learned vocalization is a rare trait shared by humans and songbirds, but not found in most mammals. Birdsong has been a tractable model system for investigating the neural basis of learned vocal control and plasticity. The basal ganglia circuit contributes to motor control and is involved in numerous movement disorders, including speech deficits. We are interested in the role of the counterpart circuit in songbirds in adult vocal plasticity. It could also be helpful to understand speech control and plasticity in humans.


Selected Publications

♦ Research Articles

1. Jie Li, Xin Zhou, Li Huang, Xin Fu, Jin Liu, Xinwen Zhang, Yingyu Sun*, Mingxue Zuo (2013). Alteration of CaBP expression pattern in the nucleus magnocellularis following unilateral cochlear ablation in adult zebra finches. PLoS ONE 8:e79297 (*correspondence)

2. Yingyu Sun*, Wei Zhang*, Dongfeng Chen*, Yuhong Lv*, Junxiong Zheng, Henrik Lilljebjörn, Liang Ran, Zhaoshi Bao, Charlotte Soneson, Hans Olov Sjögren, Leif G. Salford, Jianguang Ji, Pim J. French, Thoas Fioretos, Tao Jiang, Xiaolong Fan (2014). A glioma classification scheme based on co-expression modules of EGFR and PDGFRA. Proceedings of the National Academy of Sciences of the United States of America 111: 3538-3543 (*co-first authors)

3. Xin Zhou, Xin Fu, Chun Lin, Xiaojuan Zhou, Jin Liu, Li Wang, Xinwen Zhang, Mingxue Zuo, Xiaolong Fan, Dapeng Li *, Yingyu Sun* (2017). Remodeling of dendritic spines in the avian vocal motor cortex following deafening depends on the basal ganglia circuit. Cerebral Cortex 27(5):2820-2830 (*co-correspondence)

4. Qiwei Xie, Xi Chen, HaoDeng, Danqian Liu, Yingyu Sun, Xiaojuan Zhou, Yang Yang, Hua Han (2017). An automated pipeline for bouton,spine and synapse detection of in vivo two-photon images. BioData Mining 10:40

5. Ayaz Ali Samo, Jiuyi Li, Min Zhou, Yingyu Sun, Yuan Yang, Yunqiu Zhang, Jing Li, Mark van Duin, Xuzhang Lu, Xiaolong Fan (2018). MCL1 gene co-expression module stratifies multiple myeloma and predicts response to proteasome inhibitor-based therapy. Genes Chromosomes Cancer 57:420–429


Contact Information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-13661368190

E-mail: sunyingyu@bnu.edu.cn