Biochemistry and Molecular Biology


1982-1990, MD, Peking Union Medical College, China

1990-1997, PhD, University of Connecticut, USA

1997-2001, Postdoctoral fellow, instructor, Harvard Medical School, USA

2001-2014, Professor, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, China 

2014-present, Professor, College of Life Sciences, Beijing Normal University, China


Research Interests

Early biomarker discovery in urine and etc.


Selected Publications

♦ Research Articles

1. Lulu Jia, Xuejiao Liu, Liu Liu, Mingxi Li, Youhe Gao. Urimem, a membrane that can store urinary proteins simply and economically, makes the large-scale storage of clinical samples possible. Sci China Life Sci, March 2014, 57: 336–9

2. Menglin Li, Mindi Zhao and Youhe Gao. Changes of proteins induced by anticoagulants can be more sensitively detected in urine rather than plasma. Sci China Life Sci, 2014, 57(7): 649-656.

3. Lisi Zhu, Menglin Li, Lilong Wei, Xuejiao Liu, Jianrui Yin and Youhe Gao. Fast fixing and comprehensive identification to help improve real-time ligands discovery based on formaldehyde crosslinking, immunoprecipitation and SDS-PAGE separation Proteome Science 2014, 12:6

2. Wei Yin, Weiwei Qin, Youhe Gao. Urine glucose levels are disordered before blood glucose level increase was observed in Zucker diabetic fatty rats. Sci China Life Sci. 2018; 61:844-8

3. Jianqiang Wu, Zhengguang Guo, Youhe Gao. Dynamic changes in the urine proteome of a Walker 256 tumor-bearing rat model. Cancer Med. 2017; 6:2713-22

4. Jianqiang Wu, Xundou Li, Mindi Zhao, He Huang, Wei Sun, and Youhe Gao. Early detection in urinary proteome for effective early treatment of bleomycin-induced pulmonary fibrosis in rat model. Proteomics Clin Appl. 2017; 11(11-12).

5. Yanying Ni, Fanshuang Zhang, Manxia An, Wei Yin and Youhe Gao. Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI. Sci China Life Sci. 2018; 61:982-7

6. Fanshuang Zhang, Jing Wei, Xundou Li, Chao Ma, Youhe Gao. Early candidate urine biomarkers for detecting Alzheimer's disease before beta amyloid plaque deposition in an APP (swe)/PSEN1dE9 transgenic mouse model. J Alzheimers Dis. 2018; 66:613–37

7. Yongtao Liu, Youzhu Wang, Zhixiang Cao, Youhe Gao. Changes in the Urinary Proteome in a Patient-Derived Xenograft (PDX) Nude Mouse Model of Colorectal Tumor. Sci Rep. 2019 9:4975-84.

8. Jing Wei, Na Ni, Linpei Zhang, Youhe Gao. Early candidate biomarkers in urine of Walker-256 lung metastasis rat model. Scientific Reports (2019) 9:13804

9. Jing Wei, Wenshu Meng, Youhe Gao. Urine proteome changes in rats with approximately ten tumor cells subcutaneous inoculation PeerJ. 2019 Sep 17;7:e7717.

10. 刘永涛,赵敏迪,潘宣圳,高友鹤. 健康人的尿液中为什么会有蛋白质?中国科学: 生命科学2020,50(3), 338-348.


♦ Books / Chapters

1. Urine Promising Biomarker Source for Early Disease Detection Gao, Youhe (Ed.) 2019 Springer Nature Singapore Pte Ltd.

2. 《蛋白质组学与精准医学》上海交通大学出版社 2017 尿液蛋白质组研究及其应用

3. 《中国生物样本库--理论与实践(精)》科学出版社2017尿液生物样本库及其应用

4. Urine Proteomics in Kidney Disease Biomarker Discovery, Series: Advances in Experimental Medicine and Biology, Vol. 845 Gao, Youhe (Ed.) 2015 Springer

5. Renal and Urinary Proteomics Methods and Protocols, 2009 Wiley, Chapters: Enrichment and Analysis of Concanavalin A-Captured Urinary Glycoproteins; Liquid Chromatography Coupled to Mass Spectrometry for Analysis of the Urinary Proteome


♦ Opinions

1. 高友鹤. 尿液有可能成为生物标志物的金矿吗? 中国科学 生命科学, 2013, 43(8): 708-708

2. Youhe Gao Roadmap to the Urine Biomarker Era. MOJ Proteomics Bioinform 2014, 1(1): 00005

3. Youhe Gao Taking a Deep Breath. MOJ Proteomics Bioinform 2015 2(4): 00055.

4. Youhe Gao Not all human being’s are created equal MOJ Proteomics Bioinform 2015 2(3): 00051.

5. Youhe Gao Facts of Research on Protein-Protein Interactions Sci China Life Sci. 2017 60(3):313-314.

6. Youhe Gao Now is the time to test early urinary biomarkers in large-scale human samples. Sci China Life Sci. 2019 Jun;62(6):851-853.

7. Youhe Gao The Urine Proteome in Toxicology. Chemical Research in Toxicology 2020 15;33(6):1281-1283.


♦ Reviews

1. Jianqiang Wu and Youhe Gao Physiological conditions can be reflected in human urine proteome and metabolome Expert Review of Proteomics 2015 12(6):623-636

2. Manxia An and Youhe Gao Urinary Biomarkers of Brain Diseases. Genomics Proteomics Bioinformatics. 2015 13(6):345-54.

3. Huan Yuhang, Qin Weiwei and Gao Youhe  Factors to consider in the verification of urinary biomarkers Sci China Life Sci. 2018 61(10):1283-1290

4. Wenshu Meng, Jing Wei and Youhe Gao Could urine biomarkers reflect different stages of disease? Curr Sci Res Biomed Sciences 2020  3(1): 180013

5. Wenshu Meng and Youhe Gao Randomized grouping statistical analysis in clinical omics biomarker discovery MOJ Proteomics Bioinform. 2020 9(3):73‒75.


Contact Information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-10-58804382

E-mail: gaoyouhe@bnu.edu.cn