Faculty
Biology
YU SHANG
Associate professor
Cancer cell biology
1999-2003, BSc, Tsinghua University, China
2003-2009, Ph.D., Tsinghua University, China
2009-2011, Postdoc., Tsinghua University, China
2011-2015, Assistant professor, Beijing Normal University, China
2015-present, Associate professor, Beijing Normal University, China
Research Interests
My laboratory is set to understand the molecular mechanisms controlling human diseases especially cancers. Current research projects in my laboratory include:
1. Investigating roles of an E3 ligase CHIP in the tumorigenesis and progression
2. Clarifying the regulation mechanism of CHIP
3. Revealing the regulation of TGF-b and other signaling pathways in cancer cells
Selected Publications
♦ Research Articles
1. Shang Y#, He J, Wang Y, Feng Q, Zhang Y, Guo J, Li J, Li S, Wang Y, Yan G et al : CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma. Oncogene 2017, 36(29):4191-4200. （#Co-corresponding author）
2. Shang Y#, Zhao X, Tian B, Wang Y, Ren F, Jia B, Zhai Y, Chen W, He D, Chang Z: CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cellular signalling 2014, 26(5):1098-1104. （#Co-corresponding author）
3. Shang Y, Xu X, Duan X, Guo J, Wang Y, Ren F, He D, Chang Z: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1. Biochemical and biophysical research communications 2014, 446(1):387-392.
4. Shang Y, Zhao X, Xu X, Xin H, Li X, Zhai Y, He D, Jia B, Chen W, Chang Z: CHIP functions an E3 ubiquitin ligase of Runx1. Biochemical and biophysical research communications 2009, 386(1):242-246.
5. Li RF, Shang Y*, Liu D, Ren ZS, Chang Z, Sui SF: Differential ubiquitination of Smad1 mediated by CHIP: implications in the regulation of the bone morphogenetic protein signaling pathway. Journal of molecular biology 2007, 374(3):777-790. （*Co-first author）
Contact Information
College of Life Sciences,
Beijing Normal University,
Beijing 100875,
P. R. China
Tel. : +86-10-58809409
E-mail: shangyu@bnu.edu.cn