Professor

 

 

Selected Publications

♦ Research Articles

1. Chen, L.B., Ma, S., Jiang, T.X., Qiu, X.-B. * (2020) Transcriptional upregulation of proteasome activator Blm10 antagonizes cellular aging. Biochem Biophys Res Commun. S0006-291X(20)31380-2. doi: 10.1016/j.bbrc.2020.07.003. Online ahead of print.

2. Jiang, T.X., Zou, J., Zhu, Q., Liu, C.H., Wang, G., Du, T., Luo, Z. Guo, F., Zhou, L., Liu, J., Zhang, W., Shu, Y., Yu, L., Li, P., Ronai, Z.A., Matsuzawa, S., Goldberg, A.L.* and Qiu, X.B.* (2019). SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc. Natl. Acad. Sci. USA 116(27):13404-13413.

3. Yin,Y.S., Zhu, Q.Q., Jiang, T.X., Fan, L.B.* and Qiu, X.-B.* (2019). Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment. Science China Life Sciences 62(8): 1078~1086.

4. Guo, Z.-Q., Zheng, T., Chen, B., Luo, C., Ouyang, S., Gong, S., Li, J., Mao, L.-L.,Lian, F., Yang, Y., Huang, Y., Li, L., Lu, J., Zhang, B., Zhou, L.-M., Ding, H., Gao, Z., Zhou, L., Li, G., Zhou, R., Chen, K., Liu, J., Wen, Y., Gong, L., Ke, Y., Yang, S.-D., Qiu, X.B., Zhang, N., Ren, J., Zhong, D., Yang, C.-G., Liu, J., and Jiang, H. (2016). Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer. Cancer Cell 30, 474–484.

5. Wang, J., Li, B.-X., Ge, P.-P., Li, J., Wang, Q., Gao, G.F.*, Qiu, X.B.*, and Liu, C.H.* (2015) Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 16, 237-245. (Cover story)

6. Qian, M., Pang, Y., Liu, C., Haratake, K., Du, B., Ji, D., Wang, G., Zhu, Q., Song, W., Yu, Y., Zhang, X., Huang, H., Miao, S., Chen, L., Zhang, Z., Liang, Y., Liu, S., Cha, H., Yang, D., Zhai, Y., Komatsu, T., Tsuruta, F., Li, H., Cao, C., Li, W., Li, G., Cheng, Y., Chiba, T., Wang, L., Goldberg, A.L., Shen, Y., and Qiu, X.B.*. (2013) Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell 53，1012-1024. (Highlighted by Cell)

7. Qiu, X.B.*, Ouyang, S.Y., Li, C.J., Miao, S., Wang, L., and Goldberg, A.L.* (2006) hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 25，5742-5753.

8. Qiu, X.B.* and Goldberg, A. L.* (2005) The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J. Biol. Chem.  280,174-182.

9. Qiu, X.B.*, Markant, S.L., Yuan, J., and Goldberg, A.L.* (2004) Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 23, 800-810.

10. Qiu, X.B.* and Goldberg, A. L.* (2002) Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3.  Proc Natl Acad Sci U S A  99, 14843-14848.

 

Contact Information

College of Life Sciences,

Beijing Normal University,

Beijing 100875,

P. R. China

Tel. : +86-10-58808117

E-mail: xqiu@bnu.edu.cn